Dickkopf-1 in human oral cancer
نویسندگان
چکیده
منابع مشابه
The complex life of DICKKOPF-1 in cancer cells
Departamento de Biología del Cáncer, Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas (CSIC) – Universidad Autónoma de Madrid (UAM), Madrid, E-28029, Spain Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, E-28029, Spain Departamento de Anatomía Patológica, Instituto de Investigación Sanitaria Fundaci...
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Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was first described 25 years ago for its function in head induction and limb morphogenesis. Since then, this protein has been widely studied in the context of active Wnt/β-catenin signalling during cellular differentiation and development. Dysregulation of DKK1 has been associated with bone pathologie...
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Prokineticin 1 (PROK1) signalling via prokineticin receptor 1 (PROKR1) regulates the expression of several genes with important roles in endometrial receptivity and implantation. This study investigated PROK1 regulation of Dickkopf 1 (DKK1) expression, a negative regulator of canonical Wnt signalling, and its function in the non-pregnant endometrium and first trimester decidua. DKK1 mRNA expres...
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Dickkopf-1 (DKK1) is an inhibitor of the Wnt/β-catenin signaling pathway. However, the role of DKK1 in the progression of non small cell lung cancer (NSCLC) is not fully understood. In this study, RT-PCR and Western blot were used to examine the expression of DKK1 in a panel of ten human NSCLC cell lines and NSCLC tissues. DKK1 expression was highly transactivated in the great majority of these...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2011
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2011.1046